Physical and Pharmacological Effects of Marijuana
Cannabis is not only the most mistreated illicit drug in the united states (Gold, Frost-Pineda, & Jacobs, 2004; NIDA, 2010) it is in fact the most mistreated illegal drug worldwide (UNODC, 2010). In the united states it is a schedule-I substance which means that it is legally considered as having no dankwoods for sale Europe medical use and it is highly paralyzing (US DEA, 2010). Doweiko (2009) explains that not all cannabis has abuse potential. He therefore suggests using the common terminology Marijuana when referring to cannabis with abuse potential. For the health of clarity this terminology is used in this paper as well.
Today, Marijuana is at the forefront of international controversy discussing the appropriateness of its widespread illegal status. In many Union states it has become legalized for medical purposes. This trend is known as “medical Marijuana inch and is strongly applauded by advocates while simultaneously loathed roughly by opponents (Dubner, 2007; Nakay, 2007; Van Tuyl, 2007). It is in this context that it was decided to choose the topic of the physical and pharmacological effects of Marijuana for the basis of this research article.
What is Marijuana?
Marijuana is a plant more correctly called cannabis sativa. As mentioned, some cannabis sativa plants do not have abuse potential and are called hemp. Hemp is used widely for various fiber products including newspaper and artist’s canvas. Cannabis sativa with abuse potential is what we call Marijuana (Doweiko, 2009). It is interesting to note that although widely studies for many years, there is a lot that researchers still have no idea of about Marijuana. Neuroscientists and biologists know what the effects of Marijuana are but they still do not understand that why (Hazelden, 2005).
Deweiko (2009), Gold, Frost-Pineda, & Jacobs (2004) point out that of approximately four hundred known chemicals found in the cannabis plants, researchers know of over 58 that are thought to have psychoactive effects on the human brain. The most well known and potent of these is â-9-tetrahydrocannabinol, or THC. Like Hazelden (2005), Deweiko states that while we know many of the neurophysical effects of THC, the reasons THC produces these effects are unclear.
As a psychoactive substance, THC directly affects the central nervous system (CNS). It affects a massive choice of neurotransmitters and catalyzes other biochemical and enzymatic activity as well. The CNS is stimulated when the THC activates specific neuroreceptors in the brain causing the various physical and emotional reactions that will be expounded on more specifically further on. The only substances that can activate neurotransmitters are substances that simulate chemicals that the brain produces naturally. The fact that THC stimulates brain function teaches scientists that the brain has natural cannabinoid receptors. It is still unclear why humans have natural cannabinoid receptors and how they work (Hazelden, 2005; Martin, 2004). What we honestly do know is that Marijuana will stimulate cannabinoid receptors up to twenty times more try really hard to than any of the body is natural neurotransmitters ever could (Doweiko, 2009).
Maybe the biggest mystery of all is the relationship between THC and the neurotransmitter serotonin. Serotonin receptors are among the most stimulated by all psychoactive drugs, but most specifically alcohol and pure nicotine. Independent of Marijuana ‘s relationship with the chemical, serotonin has already been a little understood neurochemical and its supposed neuroscientific roles of functioning and purpose are still mostly hypothetical (Schuckit & Tapert, 2004). What neuroscientists have found definitively is that Marijuana smokers have very high levels of serotonin activity (Hazelden, 2005). I would hypothesize that it may be this relationship between THC and serotonin that explains the inch Marijuana maintenance program” of achieving abstinence from alcohol and allows Marijuana smokers to avoid painful withdrawal symptoms avoiding cravings from alcohol. The efficacy of inch Marijuana maintenance” for helping out alcohol abstinence is not scientific but is a phenomenon I have personally witnessed with numerous clients.
Interestingly, Marijuana mimics so many neurological reactions of other drugs that it is extremely difficult to classify in a specific class. Researchers will erect it in any of these categories: psychedelic; hallucinogen; or serotonin inhibitor. It has properties that simulate similar chemical tendencies as opioids. Other chemical tendencies simulate stimulants (Ashton, 2001; Gold, Frost-Pineda, & Jacobs, 2004). Hazelden (2005) classifies Marijuana in its very own special class — cannabinoids. The reason for this confusion is the complication of the numerous psychoactive properties found within Marijuana, both known and unknown. One recent client I saw could not live through the visual distortions he suffered as a result of pervasive psychedelic use as long as he was still smoking Marijuana. This have also been as a result of the psychedelic properties found within active cannabis (Ashton, 2001). Although not strong enough to produce these visual distortions on its own, Marijuana was strong enough to prevent serotonin levels from healing and regaining.
Cannibinoid receptors are located throughout the brain thus which affects a wide variety of functioning. The most important on the emotional level is the stimulation of the brain’s nucleus accumbens perverting the brain’s natural reward centers. Another is that of the amygdala which controls one’s emotions and fears (Adolphs, Trane, Damasio, & Damaslio, 1995; Van Tuyl, 2007).
I have observed that the heavy Marijuana smokers who I work with personally often share a commonality of using the drug to manage their wrath. This question has signaled based consequences and is the foundation of much scientific research. Research has in fact found that the relationship between Marijuana and managing wrath is scientifically significant (Eftekhari, Turner, & Larimer, 2004). Wrath is a defense mechanism used to guard against emotional consequences of adversity fueled by fear (Cramer, 1998). As stated, fear is a primary function controlled by the amygdala which is heavily stimulated by Marijuana use (Adolphs, Trane, Damasio, & Damaslio, 1995; Van Tuyl, 2007).
Neurophysical Effects of THC:
Neurological messages between transmitters and receptors not only control emotions and psychological functioning. It is also how the body controls both volitional and nonvolitional functioning. The cerebellum and the basal ganglia control all real movement and coordination. These are two of the most abundantly stimulated areas of serotonin levels that are triggered by Marijuana. This explains Marijuana ‘s physical effect causing altered blood pressure (Van Tuyl, 2007), and a weakening of the muscles (Doweiko, 2009). THC ultimately affects all neuromotor activity to some degree (Gold, Frost-Pineda, & Jacobs, 2004).
An interesting phenomena I have witnessed in almost all clients who identify Marijuana as their drug of choice is the use of Marijuana smoking before eating. This is explained by effects of Marijuana on the “CB-1” receptor. The CB-1 receptors in the brain are found heavily in the limbic system, or the nucleolus accumbens, which controls the reward trails (Martin, 2004). These reward trails are what affect the appetite and eating habits as part of the body is natural your survival thought, causing us to crave consuming food and rewarding us with dopamine when we finally do (Hazeldon, 2005). Martin (2004) makes this connection, pointing out that unique to Marijuana users is the stimulation of the CB-1 receptor directly triggering the appetite.
What is high grade and low grade?
A current client of quarry explains how he originally been smokers up to fifteen joints of “low grade” Marijuana daily but eventually switched to “high grade” when the low grade was commencing to prove ineffective. In the end, fifteen joints of high grade Marijuana were becoming ineffective for him as well. He often failed to get his “high” from that either. This entire process occurred within five years of the consumer’s first ever experience with Marijuana. What is high and low grade Marijuana, and why would Marijuana will lose its effects after a while?
The capacity of Marijuana is measured by the THC content within. As the market on the street becomes more competitive, the capacity on the street becomes more pure. It’s caused a trend in ever rising capacity that behaves to demand. One average joint of Marijuana been smokers today has the equivalent THC capacity as ten average joints of Marijuana been smokers during the 1960’s (Hazelden, 2005).
THC levels is based on mainly on the amount section of the cannabis leaf is being used for production. For instance cannabis buds can be between two to nine times stronger than fully developed leaves. Hash oil, a form of Marijuana developed by distilling cannabis resin, can yield higher levels of THC than even high grade buds (Gold, Frost-Pineda, & Jacobs, 2004).
The need to raise the amount of Marijuana one smokes, or the need to intensify from low grade to high grade is known scientifically as ceiling. Serotonin levels is efficient. As it knows that neuroreceptors are being stimulated without the neurotransmitters emitting those chemical signals, serotonin levels resourcefully lessens its chemical output so the total levels are back to normal. The smoker will not feel the high anymore as his brain is now “tolerating” the higher levels of chemicals and he or she is back to feeling normal. The smoker now raises the amount to get the old high back and the cycle continues. The smoker might discover switching up in grades effective for a while. Eventually serotonin levels can cease to produce the chemical altogether, entirely relying on the synthetic version being ingested (Gold, Frost-Pineda, & Jacobs, 2004; Hazelden, 2005).
Why isn’t there any withdrawal?
The flip side of the ceiling process is known as “dependence. inch As the body stops producing its very own natural chemicals, it now needs the Marijuana user to continue smoking in order to continue the functioning of chemicals without being interrupted. The body is now ordering the ingestion of the THC making it extremely difficult to quit. In fact, studies show that Marijuana dependency is even more powerful than seemingly harder drugs like cocaine (Gold, Frost-Pineda, & Jacobs, 2004).
With quitting other drugs like stimulants, opioids, or alcohol the body replies in negative and sometimes severely dangerous ways. This is due to the sudden lack of chemical input tied together with the fact that serotonin levels has stopped its very own natural neurotransmission of those chemicals long ago. This is the phenomenon of withdrawal (Haney, 2004; Hazelden, 2005; Jaffe & Jaffe, 2004; Tabakoff & Hoffman, 2004).
While research has shown comparable withdrawal reactions is Marijuana users just as alcohol or other drugs (Ashton, 2001), what I have witnessed many times in my personal interaction with clients is the apparent lack of withdrawal experienced by most Marijuana users. Of course they experience cravings, but they don’t report having the same neurophysical withdrawal reaction that the other drug users have. Some Marijuana smokers take advantage of this as their final proof that Marijuana “is not a drug” and they should therefore not be subjugated to the same treatment and pursuit of recovery efforts as other drug or alcohol abusers.
The reality is that the seemingly lack of acute withdrawal is a product of the uniqueness of how the body stores THC. While alcohol and other drugs are out of the human being system within a one to five days (Schuckit & Tapert, 2004), THC can take up to month until it is fully expelled from the body (Doweiko, 2009). When THC is ingested by the smoker, it is initially distributed very rapidly through the heart, lungs, and brain (Ashton, 2001). THC however, is eventually converted into protein and becomes stored is body fat and muscle. This second process of storage in body fat reserve is a far slower process. When the user begins abstinence, fat stored THC begins its slow release back into the body. While the rate of reentry into the body is system is too slow to produce any psychoactive effects, it will help out with easing the former smoker through the withdrawal process in a more manageable and pain free manner. The more one smokes the more one stores. The more body mass the smoker has, the more THC can be stored up as well (Doweiko, 2009). Thus, in very big clients I have seen it take up to month before urine screens show a cleared THC level.
Similar to THC’s slow taper like cleansing is the slow rate of initial onset of psychoactive response. Clients report that they can’t get high smoking Marijuana right away — it takes them time for their bodied to get accustomed to it before they feel the high. This is explained by the slow absorption of THC into fatty tissue reaching peak levels in 4-5 days. As the THC begins to liberate slowly into the body, the physical response will become enhanced rapidly with every new smoking of Marijuana resulting in another high. As the user repeats this process and high levels of THC accumulate in the body and continue to reach serotonin levels, the THC is finally distributed to the neocortical, limbic, sensory, and motor areas that were detailed earlier (Ashton, 2001).
The neurology and neurophysiology of Marijuana has been described so far. There are many physical components of Marijuana smoking as well. National Institute on Substance abuse (2010) reports that Marijuana smokers can have many of the same respiratory : problems as tobacco smokers including daily cough, phlegm production, more frequent acute chest illness, and a enhanced risk of lung infections. They quote research showing evidence that chronic Marijuana smokers, who do not smoke tobacco, have more health problems than not for smokers because of respiratory : illnesses.
The definitive research documenting the significant negative biophysical health effects of Marijuana is not certain. We honestly do know that Marijuana smoke contains fifty to seventy percent more carcinogenic hydrocarbons than tobacco smoke does (Ashton, 2001; Gold, Frost-Pineda, & Jacobs, 2004; NIDA, 2010). While some research ensures that Marijuana smokers show dysregulated growth of epithelial cells in their lung tissue which can lead to cancer, other studies have shown no positive associations at all between Marijuana use and lung, superior respiratory :, or superior intestines cancers (NIDA, 2010). Maybe the most eye opening fact of all is that all experts agree that historically there has yet to be a single documented death reported purely as a result of Marijuana smoking (Doweiko, 2009; Gold, Frost-Pineda, & Jacobs, 2004; Nakaya, 2007; Van Tuyl, 2007).
Pharmacology — “Medical Marijuana inch:
This last fact the seemingly less harmful effects of Marijuana smoking even which have a practical legal drugs like alcohol and pure nicotine is most often the very first estimated by proponents of legalizing Marijuana for its positive medical advantages (Dubner, 2007; Nakaya, 2007; Van Tuyl, 2007). Nakaya (2007) points to the seemingly positive effects of Marijuana on alzheimers, cancer, multiple sclerosis, glaucoma, and AIDS. While not scientific, personal experiences of the positive relief of sufferers from chronic illness is estimated as benefits that are claimed to outweigh the unwanted side effects.
Van Tuyl (2007) states “almost all drugs — including those that are legal — pose greater threats to individual health and/or society than does Marijuana. inch She believes that legalizing the smoking of Marijuana would not justify the positive effects but posits still that the risks associated with smoking can be “mitigated by alternate routes of administration, such as vaporization” (pg. 22-23). The arguments specify scientifically riskier drugs like opioids, benzodiazepines, and amphetamines that are administered by prescription on a daily basis. These drugs, like Vicodine, Xanex, or Ritalin, are internationally acceptable when deemed “medically necessary. inch
Conclusion or Manifestation:
While I am unpleasant weighing in on the controversy of the legalization of Marijuana, in conclusion of this research paper there are clear significances for me as a practitioner. Alcohol too is quite legal, as is pure nicotine, but for the addiction counselor it is important to continue keeping a directive on the biopsychosocial considerations the neglect of any substance. Because of the large lack of empirical knowledge the neurobiological properties associated with exact brain functioning, a significant focus moving forward will make monitoring breakthrough breakthrough discoveries in the neuroscience of THC and other cannabanoids. The breakthrough discoveries of particular importance for current practice are the pathology of Marijuana ‘s relationship with emotional self-medication, ceiling, and most of all the withdrawal process. I have already initiated to utilize the knowledge of the physical and pharmacological effects of Marijuana expressed heretofore with personal success and look forward to continue utilizing for more distance research to do the same.